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KMID : 0191120200350460393
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Journal of Korean Medical Science
2020 Volume.35 No. 46 p.393 ~ p.393
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Clinical Characteristics and Treatment Outcomes in Children, Adolescents, and Young-adults with Hodgkin's Lymphoma: a KPHOG Lymphoma Working-party, Multicenter, Retrospective Study
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Lee Jae-Min
Choi Jung-Yoon
Hong Kyung-Taek
Kang Hyoung-Jin
Shin Hee-Young
Baek Hee-Jo
Kook Hoon
Kim Seong-Koo
Lee Jae-Wook
Chung Nack-Gyun
Cho Bin
Cho Seok-Goo
Park Kyung-Mi
Yang Eu-Jeen
Lim Young-Tak
Suh Jin-Kyung
Kang Sung-Han
Kim Hye-Ry
Koh Kyung-Nam
Im Ho-Joon
Seo Jong-JIn
Cho Hee-Won
Ju Hee-Young
Lee Ji-Won
Yoo Keon-Hee
Sung Ki-Woong
Koo Hong-Hoe
Park Kyung-Duk
Hah Jeong-Ok
Kim Min-Kyoung
Han Jung-Woo
Hahn Seung-Min
Lyu Chuhl-Joo
Shim Ye-Jee
Kim Heung-Sik
Do Young-Rok
Yoo Jae-Won
Lim Yeon-Jung
Jeon In-Sang
Chueh Hee-Won
Oh Sung-Yong
Choi Hyoung-Soo
Park Jun-Eun
Lee Jun-Ah
Park Hyeon-Jin
Park Byung-Kiu
Kim Soon-Ki
Lim Jae-Young
Park Eun-Sil
Park Sang-Kyu
Choi Eun-Jin
Choi Young-Bae
Yoon Jong-Hyung
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Abstract
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Background: Hodgkin's lymphoma (HL) constitutes 10%?20% of all malignant lymphomas and has a high cure rate (5-year survival, around 90%). Recently, interest has increased concerning preventing secondary complications (secondary cancer, endocrine disorders) in long-term survivors. We aimed to study the epidemiologic features and therapeutic outcomes of HL in children, adolescents, and young adults in Korea.
Methods: We performed a multicenter, retrospective study of 224 patients aged < 25 years diagnosed with HL at 22 participating institutes in Korea from January 2007 to August 2016.
Results: A higher percentage of males was diagnosed at a younger age. Nodular sclerosis histopathological HL subtype was most common, followed by mixed cellularity subtype. Eighty-one (36.2%), 101 (45.1%), and 42 (18.8%) patients were classified into low, intermediate, and high-risk groups, respectively. Doxorubicin, bleomycin, vinblastine, dacarbazine was the most common protocol (n = 102, 45.5%). Event-free survival rate was 86.0% ± 2.4%, while five-year overall survival (OS) rate was 96.1% ± 1.4%: 98.7% ± 1.3%, 97.7% ± 1.6%, and 86.5% ± 5.6% in the low, intermediate, and high-risk groups, respectively (P = 0.021). Five-year OS was worse in patients with B-symptoms, stage IV disease, high-risk, splenic involvement, extra-nodal lymphoma, and elevated lactate dehydrogenase level. In multivariate analysis, B-symptoms and extra-nodal involvement were prognostic factors for poor OS. Late complications of endocrine disorders and secondary malignancy were observed in 17 and 6 patients, respectively.
Conclusion: This is the first study on the epidemiology and treatment outcomes of HL in children, adolescents, and young adults in Korea. Future prospective studies are indicated to develop therapies that minimize treatment toxicity while maximizing cure rates in children, adolescents, and young adults with HL.
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KEYWORD
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Hodgkin Lymphoma, Children, Adolescent, Young Adult, Late Complication
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